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Human polymorphisms in GSDMD alter the inflammatory response

Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation than the majority of other gene families. However, the phenotypic implications of this genetic variation are not well understood, with effects ranging from hypomorphic to silent to hyperfunctioning....

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Rathkey, Joseph K., Xiao, Tsan S., Abbott, Derek W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062166/
https://ncbi.nlm.nih.gov/pubmed/31988247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010604
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