FRA1 contributes to MEK-ERK pathway-dependent PD-L1 upregulation by KRAS mutation in premalignant human bronchial epithelial cells

Oncogenic KRAS mutations are frequently found in non-small cell lung carcinoma (NSCLC) and cause constitutive activation of the MEK-ERK pathway. Many cancer types have been shown to overexpress PD-L1 to escape immune surveillance. FRA1 is a MEK/ERK-dependent oncogenic transcription factor and a memb...

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Bibliographic Details
Published in:Am J Transl Res
Main Authors: Lee, Mi-Heon, Yanagawa, Jane, Tran, Linh, Walser, Tonya C, Bisht, Bharti, Fung, Eileen, Park, Stacy J, Zeng, Gang, Krysan, Kostyantyn, Wallace, William D, Paul, Manash K, Girard, Luc, Gao, Boning, Minna, John D, Dubinett, Steven M, Lee, Jay M
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061839/
https://ncbi.nlm.nih.gov/pubmed/32194893
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