FRA1 contributes to MEK-ERK pathway-dependent PD-L1 upregulation by KRAS mutation in premalignant human bronchial epithelial cells

Oncogenic KRAS mutations are frequently found in non-small cell lung carcinoma (NSCLC) and cause constitutive activation of the MEK-ERK pathway. Many cancer types have been shown to overexpress PD-L1 to escape immune surveillance. FRA1 is a MEK/ERK-dependent oncogenic transcription factor and a memb...

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Udgivet i:Am J Transl Res
Main Authors: Lee, Mi-Heon, Yanagawa, Jane, Tran, Linh, Walser, Tonya C, Bisht, Bharti, Fung, Eileen, Park, Stacy J, Zeng, Gang, Krysan, Kostyantyn, Wallace, William D, Paul, Manash K, Girard, Luc, Gao, Boning, Minna, John D, Dubinett, Steven M, Lee, Jay M
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2020
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061839/
https://ncbi.nlm.nih.gov/pubmed/32194893
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