β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates

Multiple G protein-coupled receptors (GPCRs) are targets in the treatment of dementia, and the arrestins are common to their signaling. β-Arrestin2 was significantly increased in brains of patients with frontotemporal lobar degeneration (FTLD-tau), a disease second to Alzheimer’s as a cause of demen...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Woo, Jung-A A., Liu, Tian, Fang, Cenxiao C., Castaño, Maria A., Kee, Teresa, Yrigoin, Ksenia, Yan, Yan, Cazzaro, Sara, Matlack, Jenet, Wang, Xinming, Zhao, Xingyu, Kang, David E., Liggett, Stephen B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060747/
https://ncbi.nlm.nih.gov/pubmed/32071246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917194117
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