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Direct observation of ligand migration within human hemoglobin at work

Hemoglobin is one of the best-characterized proteins with respect to structure and function, but the internal ligand diffusion pathways remain obscure and controversial. Here we captured the CO migration processes in the tense (T), relaxed (R), and second relaxed (R2) quaternary structures of human...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shibayama, Naoya, Sato-Tomita, Ayana, Ohki, Mio, Ichiyanagi, Kouhei, Park, Sam-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060717/
https://ncbi.nlm.nih.gov/pubmed/32071219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913663117
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