Visualizing breathing motion of internal cavities in concert with ligand migration in myoglobin

Proteins harbor a number of cavities of relatively small volume. Although these packing defects are associated with the thermodynamic instability of the proteins, the cavities also play specific roles in controlling protein functions, e.g., ligand migration and binding. This issue has been extensive...

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Autori principali: Tomita, Ayana, Sato, Tokushi, Ichiyanagi, Kouhei, Nozawa, Shunsuke, Ichikawa, Hirohiko, Chollet, Matthieu, Kawai, Fumihiro, Park, Sam-Yong, Tsuduki, Takayuki, Yamato, Takahisa, Koshihara, Shin-ya, Adachi, Shin-ichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637904/
https://ncbi.nlm.nih.gov/pubmed/19204297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807774106
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