The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Parkinson’s disease (PD) is characterized by the accumulation of misfolded and aggregated α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is widely believed that α-syn plays a central role in the pathogenesis of PD, the processes that govern α-syn fibrillizatio...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Mahul-Mellier, Anne-Laure, Burtscher, Johannes, Maharjan, Niran, Weerens, Laura, Croisier, Marie, Kuttler, Fabien, Leleu, Marion, Knott, Graham W., Lashuel, Hilal A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060668/
https://ncbi.nlm.nih.gov/pubmed/32075919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913904117
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