Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin

Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection. Improper lubricin modification and degradation has been observed in idiopathic osteoarthritis (OA), while the detailed mechanism still remains unk...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Huang, Shan, Thomsson, Kristina A., Jin, Chunsheng, Alweddi, Sally, Struglics, André, Rolfson, Ola, Björkman, Lena I., Kalamajski, Sebastian, Schmidt, Tannin A., Jay, Gregory D., Krawetz, Roman, Karlsson, Niclas G., Eisler, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060204/
https://ncbi.nlm.nih.gov/pubmed/32144329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61161-5
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