Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin

Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection. Improper lubricin modification and degradation has been observed in idiopathic osteoarthritis (OA), while the detailed mechanism still remains unk...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Huang, Shan, Thomsson, Kristina A., Jin, Chunsheng, Alweddi, Sally, Struglics, André, Rolfson, Ola, Björkman, Lena I., Kalamajski, Sebastian, Schmidt, Tannin A., Jay, Gregory D., Krawetz, Roman, Karlsson, Niclas G., Eisler, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060204/
https://ncbi.nlm.nih.gov/pubmed/32144329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61161-5
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