Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking

The synovial fluid glycoprotein lubricin (also known as proteoglycan 4) is a mucin-type O-linked glycosylated biological lubricant implicated to be involved in osteoarthritis (OA) development. Lubricin's ability to reduce friction is related to its glycosylation consisting of sialylated and uns...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Flowers, Sarah A., Thomsson, Kristina A., Ali, Liaqat, Huang, Shan, Mthembu, Yolanda, Regmi, Suresh C., Holgersson, Jan, Schmidt, Tannin A., Rolfson, Ola, Björkman, Lena I., Sundqvist, Martina, Karlsson-Bengtsson, Anna, Jay, Gregory D., Eisler, Thomas, Krawetz, Roman, Karlsson, Niclas G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681006/
https://ncbi.nlm.nih.gov/pubmed/32928962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012882
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