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Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel cause cystic fibrosis. Chaperones, including HSC70, DNAJA1 and DNAJA2, play key roles in both the folding and degradation of wild-type and mutant CFTR at multiple cellular locations. DNAJA1 and HSC70 promote the fold...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7060200/ https://ncbi.nlm.nih.gov/pubmed/32144307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61107-x |
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