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Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

Liquid-liquid phase separation (LLPS) explains many intracellular activities, but its role in extracellular functions has not been studied to the same extent. Here we report how LLPS mediates the extracellular function of galectin-3, the only monomeric member of the galectin family. The mechanism th...

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Publicado en:Nat Commun
Main Authors: Chiu, Yi-Ping, Sun, Yung-Chen, Qiu, De-Chen, Lin, Yu-Hao, Chen, Yin-Quan, Kuo, Jean-Cheng, Huang, Jie-rong
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060198/
https://ncbi.nlm.nih.gov/pubmed/32144274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15007-3
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