Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions

Under stress, certain eukaryotic proteins and RNA assemble to form membraneless organelles known as stress granules. The most well-studied stress granule components are RNA-binding proteins that undergo liquid-liquid phase separation (LLPS) into protein-rich droplets mediated by intrinsically-disord...

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Publicado no:Mol Cell
Main Authors: Dao, Thuy P., Kolaitis, Regina-Maria, Joo Kim, Hong, O’Donovan, Kevin, Martyniak, Brian, Colicino, Erica, Hehnly, Heidi, Taylor, J. Paul, Castañeda, Carlos A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181577/
https://ncbi.nlm.nih.gov/pubmed/29526694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.004
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