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ALS-linked mutations affect UBQLN2 oligomerization and phase separation in a position- and amino acid-dependent manner
Proteasomal shuttle factor UBQLN2 is recruited to stress granules and undergoes liquid-liquid phase separation (LLPS) into protein-containing droplets. Mutations to UBQLN2 have recently been shown to cause dominant x-linked inheritance of ALS and ALS/dementia. Interestingly, most of these UBQLN2 mut...
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| Pubblicato in: | Structure |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6551275/ https://ncbi.nlm.nih.gov/pubmed/30982635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.03.012 |
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