ALS-linked mutations affect UBQLN2 oligomerization and phase separation in a position- and amino acid-dependent manner

Proteasomal shuttle factor UBQLN2 is recruited to stress granules and undergoes liquid-liquid phase separation (LLPS) into protein-containing droplets. Mutations to UBQLN2 have recently been shown to cause dominant x-linked inheritance of ALS and ALS/dementia. Interestingly, most of these UBQLN2 mut...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Structure
Asıl Yazarlar: Dao, Thuy P., Martyniak, Brian, Canning, Ashley J., Lei, Yongna, Colicino, Erica G., Cosgrove, Michael S., Hehnly, Heidi, Castañeda, Carlos A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551275/
https://ncbi.nlm.nih.gov/pubmed/30982635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.03.012
Etiketler: Etiketle
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