Glucocerebrosidase activity modulates neuronal susceptibility to pathological α-synuclein insult

Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson’s Disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity has been linked to accumulation of α-synuclein. The current study systematicall...

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Publicado en:Neuron
Main Authors: Henderson, Michael X., Sedor, Samantha, McGeary, Ian, Cornblath, Eli J., Peng, Chao, Riddle, Dawn M., Li, Howard L., Zhang, Bin, Brown, Hannah J., Olufemi, Modupe F., Bassett, Danielle S., Trojanowski, John Q., Lee, Virginia M.Y.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060125/
https://ncbi.nlm.nih.gov/pubmed/31899072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.12.004
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