The K(Ca)2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs

AIMS: To describe the effects of the K(Ca)2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistant atrial fibrillation (AF), and prevention of r...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Diness, Jonas Goldin, Kirchhoff, Jeppe Egedal, Speerschneider, Tobias, Abildgaard, Lea, Edvardsson, Nils, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059611/
https://ncbi.nlm.nih.gov/pubmed/32180722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00159
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