A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8(+) T Cells in Head and Neck Cancer

The limited ability of cytotoxic CD8(+) T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca(2+)-dependent signaling events control the activity of T cells and are implicated in the failure of imm...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Chimote, Ameet A., Gawali, Vaibhavkumar S., Newton, Hannah S., Wise-Draper, Trisha M., Conforti, Laura
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059094/
https://ncbi.nlm.nih.gov/pubmed/32184726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00143
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