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EXP2SL: A Machine Learning Framework for Cell-Line-Specific Synthetic Lethality Prediction

Synthetic lethality (SL), an important type of genetic interaction, can provide useful insight into the target identification process for the development of anticancer therapeutics. Although several well-established SL gene pairs have been verified to be conserved in humans, most SL interactions rem...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Wan, Fangping, Li, Shuya, Tian, Tingzhong, Lei, Yipin, Zhao, Dan, Zeng, Jianyang
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058988/
https://ncbi.nlm.nih.gov/pubmed/32184722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00112
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