Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s

Multiple myeloma (MM) is the second most prevalent hematologic malignancy. Although the use of bortezomib (BTZ) significantly improves MM therapy, intrinsic and acquired drug resistance to BTZ remains a major clinical problem. In this study, we find that Cdc37, a key co-chaperone of Hsp90, is downre...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Oncogenesis
Main Authors: Zang, Meirong, Guo, Jiaojiao, Liu, Lanting, Jin, Fengyan, Feng, Xiangling, An, Gang, Qin, Xiaoqi, Wu, Yangbowen, Lei, Qian, Meng, Bin, Zhu, Yinghong, Guan, Yongjun, Deng, Shuhui, Hao, Mu, Xu, Yan, Zou, Dehui, Wu, Minghua, Qiu, Lugui, Zhou, Wen
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2020
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058164/
https://ncbi.nlm.nih.gov/pubmed/32139666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-0216-1
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