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RECURRING GENOMIC STRUCTURAL VARIATION LEADS TO CLONAL INSTABILITY AND LOSS OF PRODUCTIVITY
Chinese Hamster Ovary (CHO) cells, commonly used in the production of therapeutic proteins, are aneuploid. Their chromosomes bear structural abnormality and undergo changes in structure and number during cell proliferation. Some production cell lines are unstable and lose their productivity over tim...
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| Publicado no: | Biotechnol Bioeng |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7058117/ https://ncbi.nlm.nih.gov/pubmed/30144379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26823 |
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