Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation

Flavin mononucleotide (FMN) belongs to the group of very efficient endogenous photosensitizers producing singlet oxygen, (1)O(2), but with limited ability to be targeted. On the other hand, in genetically-encoded photosensitizers, which can be targeted by means of various tags, the efficiency of FMN...

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Vydáno v:Sci Rep
Hlavní autoři: Petrenčáková, Martina, Filandr, František, Hovan, Andrej, Yassaghi, Ghazaleh, Man, Petr, Kožár, Tibor, Schwer, Marc-Simon, Jancura, Daniel, Plückthun, Andreas, Novák, Petr, Miškovský, Pavol, Bánó, Gregor, Sedlák, Erik
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058016/
https://ncbi.nlm.nih.gov/pubmed/32139757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60861-2
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