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Click Chemistry-Based Two-Component System for Efficient Inhibition of Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT)
[Image: see text] We synthesized two dTTP analogues for copper-free “click” chemistry-coupling in the active sites of DNA polymerases. We found that in the presence of both analogues, human immunodeficiency virus (HIV) reverse transcriptase (RT) activity was suppressed by up to 93%. This inhibitory...
Gorde:
| Argitaratua izan da: | ACS Omega |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical Society
2020
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7057708/ https://ncbi.nlm.nih.gov/pubmed/32149246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b03942 |
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