Wordt geladen...
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization
Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for thera...
Bewaard in:
| Gepubliceerd in: | Acta Crystallogr F Struct Biol Commun |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
International Union of Crystallography
2020
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7057348/ https://ncbi.nlm.nih.gov/pubmed/32133997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X20001466 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|