T-Cell Proapoptotic and Antifibrotic Activity Against Autologous Skin Fibroblasts in vitro Is Associated With IL-17A Axis Upregulation in Systemic Sclerosis

Background: Systemic sclerosis (SSc) T cells can induce apoptosis of autologous skin fibroblasts in vitro. Th17 cells have been reported to increase in SSc patients, and interleukin-17A (IL-17A) has a profibrotic function. We used a system based on T-cell-autologous fibroblast co-cultures to further...

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Publicado en:Front Immunol
Autores principales: Vettori, Serena, Barra, Giusi, Russo, Barbara, Borgia, Alessia, Pasquale, Giuseppe, Pellecchia, Luciana, Vicedomini, Lucia, De Palma, Raffaele
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056890/
https://ncbi.nlm.nih.gov/pubmed/32174912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00220
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