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Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
Heightened production of collagen and other matrix proteins underlies the fibrotic phenotype of systemic sclerosis (SSc). Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and control transcription (CDK7,9). In an in vivo glomeru...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3502367/ https://ncbi.nlm.nih.gov/pubmed/23185265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048560 |
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