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Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
Heightened production of collagen and other matrix proteins underlies the fibrotic phenotype of systemic sclerosis (SSc). Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and control transcription (CDK7,9). In an in vivo glomeru...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3502367/ https://ncbi.nlm.nih.gov/pubmed/23185265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048560 |
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