Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma

Nuclear import, mediated in part by karyopherin-α (KPNA)/importin-α subtypes, regulates transcription factor access to the genome and determines cell fate. However, the cancer-specific changes of KPNA subtypes and the relevancy in cancer biology remain largely unknown. Here, we report that KPNA4, en...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Hazawa, Masaharu, Sakai, Kie, Kobayashi, Akiko, Yoshino, Hironori, Iga, Yoshihiro, Iwashima, Yuki, Lim, Kee Sing, Chih-Cheng Voon, Dominic, Jiang, Yan-Yi, Horike, Shin-ichi, Lin, De-Chen, Wong, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056645/
https://ncbi.nlm.nih.gov/pubmed/31822798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1137-3
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