Site-specific PEGylation of anti-mesothelin recombinant immunotoxins increases half-life and anti-tumor activity

Recombinant Immunotoxins (RITs) are chimeric proteins containing an Fv that binds to tumor cells, fused to a fragment of Pseudomonas exotoxin (PE) that kills the cell. Their efficacy is limited by their short half-life in the circulation. Chemical modification with polyethylene glycol (PEG) is a wel...

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Pubblicato in:Mol Cancer Ther
Autori principali: Zheng, Zeliang, Okada, Ryuhei, Kobayashi, Hisataka, Nagaya, Tadanobu, Wei, Junxia, Zhou, Qi, Lee, Fred, Bera, Tapan K, Gao, Yun, Kuhlman, William, Tai, Chin-Hsien, Pastan, Ira
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056543/
https://ncbi.nlm.nih.gov/pubmed/31871266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0890
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