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Site-specific PEGylation of anti-mesothelin recombinant immunotoxins increases half-life and anti-tumor activity
Recombinant Immunotoxins (RITs) are chimeric proteins containing an Fv that binds to tumor cells, fused to a fragment of Pseudomonas exotoxin (PE) that kills the cell. Their efficacy is limited by their short half-life in the circulation. Chemical modification with polyethylene glycol (PEG) is a wel...
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| Publié dans: | Mol Cancer Ther |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7056543/ https://ncbi.nlm.nih.gov/pubmed/31871266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0890 |
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