Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anti-Cancer Immunity

Immune checkpoint blockade using antibodies to cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) benefits a limited number of cancer patients. SS1P and LMB-100 are immunotoxins that target mesothelin. We observed delayed responses to SS1P in patients with mesothelioma suggesting that anti-tumor i...

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Publicat a:Cancer Immunol Res
Autors principals: Leshem, Yasmin, O’Brien, James, Liu, Xiufen, Bera, Tapan K., Terabe, Masaki, Berzofsky, Jay A, Bossenmaier, Birgit, Niederfellner, Gerhard, Tai, Chin-Hsien, Reiter, Yoram, Pastan, Ira
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549555/
https://ncbi.nlm.nih.gov/pubmed/28674083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0330
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