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Generation of a Transgenic BALB/c Mouse Line with Selective Expression of Human Mesothelin in Thyroid Gland: Application in Mesothelin Targeted Immunotherapy

Despite encouraging clinical results with immune checkpoint inhibitors and other types of immunotherapies, the rate of failure is still very high. The development of proper animal models which could be applied to the screening of effective preclinical antitumor drugs targeting human tumor antigens,...

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Detalhes bibliográficos
Publicado no:J Immunother
Main Authors: Bera, Tapan K., Liu, Wenlong, Leshem, Yasmin, King, Emily, Kozlov, Serguei, Pastan, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935318/
https://ncbi.nlm.nih.gov/pubmed/30933045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000263
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