Ceramide analog SACLAC modulates sphingolipid levels and Mcl-1 splicing to induce apoptosis in acute myeloid leukemia

Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation of immature myeloid cells in the blood and bone marrow. The five-year survival rate is approximately 25%, and recent therapeutic developments have yielded little survival benefit. Therefore, there is an urgent need...

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Udgivet i:Mol Cancer Res
Main Authors: Pearson, Jennifer M., Tan, Su-Fern, Sharma, Arati, Annageldiyev, Charyguly, Fox, Todd E., Abad, Jose Luis, Fabrias, Gemma, Desai, Dhimant, Amin, Shantu, Wang, Hong-Gang, Cabot, Myles C., Claxton, David F., Kester, Mark, Feith, David J., Loughran, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056541/
https://ncbi.nlm.nih.gov/pubmed/31744877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0619
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