Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in cancer cell apoptosis in response to chemotherapy....

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Kao, Li-Pin, Morad, Samy A.F., Davis, Traci S., MacDougall, Matthew R., Kassai, Miki, Abdelmageed, Noha, Fox, Todd E., Kester, Mark, Loughran, Thomas P., Abad, Jose’ L., Fabrias, Gemma, Tan, Su-Fern, Feith, David J., Claxton, David F., Spiegel, Sarah, Fisher-Wellman, Kelsey H., Cabot, Myles C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718434/
https://ncbi.nlm.nih.gov/pubmed/31363040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000251
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