Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse

Due to its dismal outcome, pancreatic cancer (PDAC) remains a therapeutic challenge making the testing of new pharmacological tools a goal of paramount importance. Here, we developed a rational approach for inhibiting PDAC growth based on leveraging cell cycle arrest of malignant cells at a phase th...

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Foilsithe in:Mol Cancer Res
Main Authors: Urrutia, Guillermo, Salmonson, Ann, Toro-Zapata, Jorge, de Assuncao, Thiago M., Mathison, Angela, Dusetti, Nelson, Iovanna, Juan, Urrutia, Raul, Lomberk, Gwen
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056528/
https://ncbi.nlm.nih.gov/pubmed/31822519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0490
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