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Radiation Induced Oxidation of [(18)F]Fluorothia Fatty Acids Under cGMP Manufacturing Conditions

OBJECTIVE: The objectives of the present work were to optimize and validate the synthesis and stability of 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ([(18)F]FTHA) and 16-[(18)F]fluoro-4-thia-palmitic acid ([(18)F]FTP) under cGMP conditions for clinical applications. METHODS: Benzyl-14-(R,S)-to...

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Publicat a:Nucl Med Biol
Autors principals: Pandey, Mukesh K, Jacobson, Mark S, Groth, Emily K, Tran, Natalie G, Lowe, Val J, DeGrado, Timothy R
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056516/
https://ncbi.nlm.nih.gov/pubmed/31759313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2019.11.004
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