Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis

Psoriasis is a systemic inflammatory disease significantly associated with comorbidities including type 2 diabetes mellitus (T2DM). Metformin is utilized as a first-line agent for treating T2DM. Although metformin reportedly inhibits mature IL-1β secretion via NLRP3 inflammasome in macrophages of T2...

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Détails bibliographiques
Publié dans:Cell Death Discov
Auteurs principaux: Tsuji, Gaku, Hashimoto-Hachiya, Akiko, Yen, Vu Hai, Takemura, Masaki, Yumine, Ayako, Furue, Kazuhisa, Furue, Masutaka, Nakahara, Takeshi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055596/
https://ncbi.nlm.nih.gov/pubmed/32194991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0245-8
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