IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis

Skin barrier dysfunction, including reduced filaggrin (FLG) and loricrin (LOR) expression, plays a critical role in atopic dermatitis (AD) development. Since aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, mediates keratinocyte differentiation, it is a potential target for...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Vu, Yen Hai, Hashimoto-Hachiya, Akiko, Takemura, Masaki, Yumine, Ayako, Mitamura, Yasutaka, Nakahara, Takeshi, Furue, Masutaka, Tsuji, Gaku
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7764126/
https://ncbi.nlm.nih.gov/pubmed/33321923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249412
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