An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity

FLT3 (FMS-like tyrosine kinase 3), expressed on the surface of acute myeloid leukemia (AML) blasts, is a promising AML target, given its role in the development and progression of leukemia, and its limited expression in tissues outside the hematopoietic system. Small molecule FLT3 kinase inhibitors...

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Vydáno v:Mol Ther
Hlavní autoři: Yeung, Yik Andy, Krishnamoorthy, Veena, Dettling, Danielle, Sommer, Cesar, Poulsen, Kris, Ni, Irene, Pham, Amber, Chen, Wei, Liao-Chan, Sindy, Lindquist, Kevin, Chin, S. Michael, Chunyk, Allison Given, Hu, Wenyue, Sasu, Barbra, Chaparro-Riggers, Javier, Djuretic, Ivana
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054815/
https://ncbi.nlm.nih.gov/pubmed/31981494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.12.014
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