Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles

Based on their identification as physiological nucleic acid carriers in humans and other organisms, extracellular vesicles (EVs) have been explored as therapeutic delivery vehicles for DNA, RNA, and other cargo. However, efficient loading and functional delivery of nucleic acids remain a challenge,...

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Pubblicato in:Mol Ther
Autori principali: Jeyaram, Anjana, Lamichhane, Tek N., Wang, Sheng, Zou, Lin, Dahal, Eshan, Kronstadt, Stephanie M., Levy, Daniel, Parajuli, Babita, Knudsen, Daphne R., Chao, Wei, Jay, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054713/
https://ncbi.nlm.nih.gov/pubmed/31911034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.12.007
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