Generation of a conditional Flpo/FRT mouse model expressing constitutively active TGFβ in fibroblasts

Transforming growth factor (TGFβ) is a secreted factor, which accumulates in tissues during many physio- and pathological processes such as embryonic development, wound healing, fibrosis and cancer. In order to analyze the effects of increased microenvironmental TGFβ concentration in vivo, we develo...

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Publicat a:Sci Rep
Autors principals: Cardot-Ruffino, Victoire, Chauvet, Véronique, Caligaris, Cassandre, Bertrand-Chapel, Adrien, Chuvin, Nicolas, Pommier, Roxane M., Valcourt, Ulrich, Vincent, David F., Martel, Sylvie, Aires, Sophie, Kaniewski, Bastien, Dubus, Pierre, Cassier, Philippe, Sentis, Stéphanie, Bartholin, Laurent
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054254/
https://ncbi.nlm.nih.gov/pubmed/32127548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60272-3
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