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Predicting Tubular Reabsorption with a Human Kidney Proximal Tubule Tissue-on-a-Chip and Physiologically-Based Modeling
Kidney is a major route of xenobiotic excretion, but the accuracy of preclinical data for predicting in vivo clearance is limited by species differences and non-physiologic 2D culture conditions. Microphysiological systems can potentially increase predictive accuracy due to their more realistic 3D e...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Toxicol In Vitro |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7053805/ https://ncbi.nlm.nih.gov/pubmed/31857146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2019.104752 |
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