Predicting Tubular Reabsorption with a Human Kidney Proximal Tubule Tissue-on-a-Chip and Physiologically-Based Modeling

Kidney is a major route of xenobiotic excretion, but the accuracy of preclinical data for predicting in vivo clearance is limited by species differences and non-physiologic 2D culture conditions. Microphysiological systems can potentially increase predictive accuracy due to their more realistic 3D e...

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Pubblicato in:Toxicol In Vitro
Autori principali: Sakolish, Courtney, Chen, Zunwei, Dalaijamts, Chimeddulam, Mitra, Kusumica, Liu, Yina, Fulton, Tracy, Wade, Terry L., Kelly, Edward J., Rusyn, Ivan, Chiu, Weihsueh A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053805/
https://ncbi.nlm.nih.gov/pubmed/31857146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2019.104752
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