Heart failure after pressure overload in autosomal-dominant desminopathies: Lessons from heterozygous DES-p.R349P knock-in mice

BACKGROUND: Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardiomyopathies, leading to heart failure, arrhythmias, and AV blocks. We analyzed the effects of vascular pressure overload in a patient-mimicking p.R349P desmin knock-in mouse model that harbors the ortho...

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Vydáno v:PLoS One
Hlavní autoři: Stöckigt, Florian, Eichhorn, Lars, Beiert, Thomas, Knappe, Vincent, Radecke, Tobias, Steinmetz, Martin, Nickenig, Georg, Peeva, Viktoriya, Kudin, Alexei P., Kunz, Wolfram S., Berwanger, Carolin, Kamm, Lisa, Schultheis, Dorothea, Schlötzer-Schrehardt, Ursula, Clemen, Christoph S., Schröder, Rolf, Schrickel, Jan W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053759/
https://ncbi.nlm.nih.gov/pubmed/32126091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228913
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