High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

High protein diets are commonly utilized for weight loss, yet have been reported to raise cardiovascular risk. The mechanisms underlying this risk are unknown. Here, we show that dietary protein drives atherosclerosis and lesion complexity. Protein ingestion acutely elevates amino acid levels in blo...

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Vydáno v:Nat Metab
Hlavní autoři: Zhang, Xiangyu, Sergin, Ismail, Evans, Trent D., Jeong, Se-Jin, Rodriguez-Velez, Astrid, Kapoor, Divya, Chen, Sunny, Song, Eric, Holloway, Karyn B., Crowley, Jan R., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Mittendorfer, Bettina, Stitziel, Nathan O., Schilling, Joel D., Lodhi, Irfan J., Razani, Babak
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053091/
https://ncbi.nlm.nih.gov/pubmed/32128508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0162-4
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