Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autoph...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Sergin, Ismail, Evans, Trent D., Zhang, Xiangyu, Bhattacharya, Somashubhra, Stokes, Carl J., Song, Eric, Ali, Sahl, Dehestani, Babak, Holloway, Karyn B., Micevych, Paul S., Javaheri, Ali, Crowley, Jan R., Ballabio, Andrea, Schilling, Joel D., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Zayed, Mohamed A., Razani, Babak
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467270/
https://ncbi.nlm.nih.gov/pubmed/28589926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15750
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