Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autoph...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Sergin, Ismail, Evans, Trent D., Zhang, Xiangyu, Bhattacharya, Somashubhra, Stokes, Carl J., Song, Eric, Ali, Sahl, Dehestani, Babak, Holloway, Karyn B., Micevych, Paul S., Javaheri, Ali, Crowley, Jan R., Ballabio, Andrea, Schilling, Joel D., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Zayed, Mohamed A., Razani, Babak
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467270/
https://ncbi.nlm.nih.gov/pubmed/28589926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15750
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