Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autoph...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Sergin, Ismail, Evans, Trent D., Zhang, Xiangyu, Bhattacharya, Somashubhra, Stokes, Carl J., Song, Eric, Ali, Sahl, Dehestani, Babak, Holloway, Karyn B., Micevych, Paul S., Javaheri, Ali, Crowley, Jan R., Ballabio, Andrea, Schilling, Joel D., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Zayed, Mohamed A., Razani, Babak
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467270/
https://ncbi.nlm.nih.gov/pubmed/28589926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15750
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