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Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism

Chronic neuroinflammation is recognized as a major neuropathological hallmark in a broad spectrum of neurodegenerative diseases including Alzheimer’s, Parkinson’s, Frontal Temporal Dementia, Amyotrophic Lateral Sclerosis, and prion diseases. Both microglia and astrocytes exhibit region-specific home...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Makarava, Natallia, Chang, Jennifer Chen-Yu, Molesworth, Kara, Baskakov, Ilia V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052953/
https://ncbi.nlm.nih.gov/pubmed/32001329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104783
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