Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle

The nongenomic mechanisms by which glucocorticoids modulate β(2) agonist-induced-bronchodilation remain elusive. Our studies aimed to elucidate mechanisms mediating the beneficial effects of glucocorticoids on agonist-induced bronchodilation. Utilizing human precision-cut lung slices (hPCLS), we mea...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Koziol-White, Cynthia, Johnstone, Timothy B., Corpuz, Maia L., Cao, Gaoyuan, Orfanos, Sarah, Parikh, Vishal, Deeney, Brian, Tliba, Omar, Ostrom, Rennolds S., Dainty, Ian, Panettieri, Reynold A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052668/
https://ncbi.nlm.nih.gov/pubmed/31747297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00393.2019
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