TRPM4 channel inhibitors 9-phenanthrol and glibenclamide differentially decrease guinea pig detrusor smooth muscle whole-cell cation currents and phasic contractions

Nonselective cation channels, consistent with transient receptor potential melastatin-4 (TRPM4), regulate detrusor smooth muscle (DSM) function. TRPM4 channels can exist as homomers or assemble with sulfonylurea receptors (SURs) as complexes. We evaluated contributions of TRPM4/SUR-TRPM4 channels to...

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Veröffentlicht in:Am J Physiol Cell Physiol
Hauptverfasser: Malysz, John, Maxwell, Sarah E., Yarotskyy, Viktor, Petkov, Georgi V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052614/
https://ncbi.nlm.nih.gov/pubmed/31851526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00055.2019
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