Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting...

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Publicado en:Nat Commun
Autores principales: Arnold, Matthias, Nho, Kwangsik, Kueider-Paisley, Alexandra, Massaro, Tyler, Huynh, Kevin, Brauner, Barbara, MahmoudianDehkordi, Siamak, Louie, Gregory, Moseley, M. Arthur, Thompson, J. Will, John-Williams, Lisa St, Tenenbaum, Jessica D., Blach, Colette, Chang, Rui, Brinton, Roberta D., Baillie, Rebecca, Han, Xianlin, Trojanowski, John Q., Shaw, Leslie M., Martins, Ralph, Weiner, Michael W., Trushina, Eugenia, Toledo, Jon B., Meikle, Peter J., Bennett, David A., Krumsiek, Jan, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Kastenmüller, Gabi
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052223/
https://ncbi.nlm.nih.gov/pubmed/32123170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14959-w
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