Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting...

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Published in:Nat Commun
Main Authors: Arnold, Matthias, Nho, Kwangsik, Kueider-Paisley, Alexandra, Massaro, Tyler, Huynh, Kevin, Brauner, Barbara, MahmoudianDehkordi, Siamak, Louie, Gregory, Moseley, M. Arthur, Thompson, J. Will, John-Williams, Lisa St, Tenenbaum, Jessica D., Blach, Colette, Chang, Rui, Brinton, Roberta D., Baillie, Rebecca, Han, Xianlin, Trojanowski, John Q., Shaw, Leslie M., Martins, Ralph, Weiner, Michael W., Trushina, Eugenia, Toledo, Jon B., Meikle, Peter J., Bennett, David A., Krumsiek, Jan, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Kastenmüller, Gabi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052223/
https://ncbi.nlm.nih.gov/pubmed/32123170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14959-w
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